Information for healthcare professionals

Safety


High precision, improving safety and reducing side effects

Delivering the radiation dose only where it is needed.

The radiation sources used for brachytherapy are placed directly in, or next to the tumor. Therefore, the irradiation effect is confined only to the target tumor being treated. In contrast, the radiation used in external beam radiotherapy (EBRT) must travel from outside the body through healthy tissue. Thus, compared to EBRT, radiation exposure to healthy tissues is much reduced with brachytherapy.

comparison of radiotherapy techniques

Precision control of radiation at the target treatment site

The radiation sources used for brachytherapy have a ‘steep dose gradient’ – at a short distance away from the radiation source, the level of radiation quickly reduces to very low levels. In physics, this is known as the ‘inverse square law’, which states that around a source of radiation, the dose ‘falls off’ at the square of the distance.

Therefore, brachytherapy enables the radiation dose and distribution of the radiation to be exactly matched to the size and shape of the tumor. Furthermore, tissues around the tumor receive a much lower dose than anticipated by other radiation methods.


Reducing side effects and improving patient outcomes

The combination of precision delivery and ‘steep dose gradient’, only found in brachytherapy, means that surrounding healthy tissues are not exposed to harmful levels of irradiation. As a result, there is less toxicity and the risk of side effects is much reduced.1-3

Brachytherapy is only minimally invasive and therefore avoids many of the risks associated with extensive surgery.


Cervical cancer

  • Brachytherapy offers reduced risk of complications and skin irritation compared to EBRT.4,5
  • Read more

Prostate cancer

  • Brachytherapy offers reduced risk of urinary, bowel and sexual function compared to EBRT.6,2
  • Brachytherapy offers reduced risk of complications compared to surgery.7-10
  • Read more

Breast cancer

  • Brachytherapy offers excellent cosmesis and minimizes radiation exposure to surrounding health breast tissue and adjacent organs and structures.11-13
  • Read more

Skin cancer

  • Brachytherapy offers improved cosmesis and a reduced need for reconstructive surgery.14-16
  • Read more

References
  1. Nag S. Technol Cancer Res Treat 2004;3(3):269–87.
  2. Ferrer M, Suarez JF, Guedea F, et al. Int J Radiat Oncol Biol Phys 2008;72(2):421–32.
  3. Frank S, Pisters L, Davis J, et al. J Urol 2007;177(6):2151–56.
  4. American Brachytherapy Society. Available at: http://www.americanbrachytherapy.org/ resources/healthapps.cfm. Accessed 30 December 2009.
  5. Stewart AJ & Viswanathan AN. Cancer 2006;107(5):908–15.
  6. Pickles T, Keyes M, Morris WJ. Int J Radiat Oncol Biol Phys 2010;76(1):43–9.
  7. Stone NN & Stock RG. Urology 2007;69(2):338–42.
  8. Moule RN & Hoskin PJ. Surg Oncol 2009;18(3):255–67.
  9. Buron C, Le Vu B, Cosset JM, et al. Int J Radiat Oncol Biol Phys 2007;67(3):812–22.
  10. Pinkawa M, Asadpour B, Piroth MD, et al. Radiother Oncol 2009;91(2):225–31.
  11. Polgár C, Major T, Fodor J, et al. Int J Radiat Oncol Biol Phys 2004;60(4):1173–81.
  12. Polgár C, Fodor J, Orosz Z, et al. Strahlenther Onkol 2002;178(11):615–23.
  13. Hoskin In: Radiotherapy in practice: brachytherapy. Hoskin P & Coyle C (Eds). Oxford, Oxford University Press. 2005.
  14. Guix B, Finestres F, Tello J, et al. Int J Radiat Oncol Biol Phys 2000;47(1):95–102.
  15. Sedda AF, Rossi G, Cipriani C, et al. Clin Exp Dermatol 2008;33(6):745–9.
  16. Rio E, Bardet E, Ferron C, et al. Int J Radiat Oncol Biol Phys 2005;63(3):753–57.
Page last updated on 14 January 2011.

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